Prolotherapy, also known as proliferative therapy, is an injection-based treatment type used in chronic musculoskeletal disorders. Treatment involves repeated injection of an irritating solution into a part of the joint, for example the interior of the joint or a supporting tendon or ligament.

Prolotherapy is completed in 30 minutes or less, including pre-procedure preparation. After the application of local anesthesia, the affected areas are carefully injected. Immediately after the treatment, the patient rests for 10-15 minutes by applying heat packs to the injection areas. After the heat application, the patient can return home.